This verse elaborates the punishment introduced in the prior verse: the ground's curse means Cain will be a restless wanderer, driven from the land.

Genesis 4:15 directly responds to Cain's fear of being killed by placing a protective mark upon him.

Genesis 4:16 directly fulfills what Cain feared: he departs from God's presence and settles in Nod — the narrative consequence of his banishment.

Genesis 4:11 states the reason for Cain's curse—his brother's blood cries out—which leads directly to his fear of being killed.

Genesis 9:6 mandates death for murderers, contrasting with God's protection of Cain and showing a shift in judicial law.

Numbers 35:27 shows what Cain fears—being killed by an avenger—is legally sanctioned for an unprotected murderer.

In Proverbs 28:1, the wicked flee with no pursuer — Cain is the prime example: terrified of being found and killed, though no one is hunting him yet.

In Psalm 143:7, the psalmist pleads 'hide not thy face from me' — the exact fate Cain suffered. A direct plea against experiencing what Cain described.

In Psalm 51:11-14, David pleads 'cast me not away from thy presence' and asks deliverance from bloodguiltiness — directly echoing Cain's fate he seeks to avoid.

Numbers 35:21 describes the avenger's right to kill the murderer—exactly the fate Cain dreads and is warned about.

Numbers 35:19 gives legal form to Cain's fear: the 'avenger of blood' is the kinsman tasked with executing justice for a murder.

In 2 Samuel 14:7, the woman's plea about the 'avenger' echoes Cain's fear of lethal familial retribution.

In 2 Thessalonians 1:9, eternal exile from the Lord's presence echoes Cain's banishment from God's face, but as final judgment.

Deuteronomy 28:65 describes restless, fearful exile among nations, mirroring Cain's sentence as a fugitive and wanderer.

In Job 21:14, the wicked say 'Depart from us' to God — the reverse of Cain. They willingly reject what Cain involuntarily lost: God's presence.

In Matthew 25:41, Jesus says 'Depart from me, ye cursed' — echoing Cain's banishment from God's presence, though applied to eternal judgment rather than temporal exile.

Leviticus 26:17 threatens that the disobedient will flee though none pursue, echoing Cain's fear of being hunted.