Genesis 21:14 depicts the immediate action following this command to send them away.

Genesis 17:19 is the prior divine decree being reaffirmed: God had already named the promised son Isaac and established His covenant with him.

Genesis 17:21 specifies the distinction: God's covenant will be established with Isaac, not Ishmael, which is the direct basis for this instruction.

In Genesis 15:4, God promised Abraham a biological heir, reinforcing that Isaac is the promised son here.

Genesis 22:2 shows another test involving Isaac, echoing the focus on him as the heir.

Romans 9:7 directly references this event, clarifying that not all Abraham's physical descendants are children of the promise—only through Isaac.

Romans 9:8 explains the principle from this story: it is the children of the promise who are counted as Abraham's offspring, not merely his biological line.

Hebrews 11:18 summarizes this moment, stating Abraham obeyed because God had told him that 'through Isaac your offspring shall be named.'

Galatians 3:16 interprets 'offspring' here as referring to Christ, applying the promise typologically.