Revelation 16:3
And the second angel poured out his vial upon the sea; and it became as the blood of a dead man: and every living soul died in the sea.
Cross-references
Revelation 8:8 describes the second trumpet turning a third of the sea to blood — a similar but partial plague, prefiguring the full sea judgment here.
Revelation 8:9 describes the second trumpet killing a third of sea creatures; the second bowl kills all — an intensification of the same judgment on the sea.
Revelation 11:6 gives the two witnesses power to turn waters to blood — the same plague of blood, now enacted on the sea by the bowl.
Exodus 7:17 records the Nile turning to blood — the OT prototype of water turned to blood, fulfilled in the eschatological bowl judgment.
Psalm 78:44 recounts the first Egyptian plague turning rivers to blood, paralleling the second bowl turning the sea to blood — both are water-to-blood judgments.
Psalm 105:29 specifically notes that the plague killed fish, directly matching the second bowl where every sea creature dies — a precise parallel.