Genesis 27:16
And she put the skins of the kids of the goats upon his hands, and upon the smooth of his neck:
Cross-reference
Genesis 27:23
Parallel
In Genesis 27:23, Isaac feels these goat skins on Jacob's hands and fails to recognize him. The disguise applied here directly causes that outcome.
Genesis 25:25
Historical context
In Genesis 25:25, Esau is born hairy — the very trait that makes goat skins necessary here to simulate his identity on Jacob's smooth skin.